Cubs vs. Cardinals Prediction, Odds, Picks – July 4

Cubs vs. Cardinals Prediction, Odds, Picks – July 4

Updated July 4, 2025, 2:00 p.m. ET

The Chicago Cubs, led by Nico Hoerner, are set to face off against the St. Louis Cardinals and Masyn Winn on Friday at 2:20 p.m. ET, kicking off a three-game series at Wrigley Field. The Cubs are favored at -144 on the moneyline, while the Cardinals, considered the underdogs, have +121 moneyline odds. Chicago also leads on the run line at -1.5, with a total run expectation of 9.5 for the matchup.

Here’s everything you need to know from a betting perspective on the Cubs-Cardinals game, including the run line, moneyline, and total, along with expert picks. Stay updated with MLB on FOX Sports.

Cubs vs. Cardinals Game Information & Odds

• When: Friday, July 4, 2025, at 2:20 p.m. ET
• Where: Wrigley Field, Chicago, Illinois
• How to watch on TV: Apple TV+

Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line Favorite	Run Line Odds	Underdog Run Line Odds
Cubs -144	+121	9.5	-103	-118	-1.5	+135	-163

Cubs vs. Cardinals Prediction

Score Prediction: Cubs 5, Cardinals 4

Total Prediction: Over 9.5 runs

Win Probabilities: Cubs 54%, Cardinals 46%

Cubs vs. Cardinals Betting Insights

The Cubs have been the favorites 60 times in 2025, securing victories in 42 of those games, translating to a 70% success rate. Chicago boasts a record of 28-9 when favored at -144 or higher on the moneyline.

With the moneyline set for this matchup, bookmakers imply a 59% chance of a Cubs win. The Cardinals have been the underdogs in 48 games this season, clinching 25 wins, which is a 52.1% success rate. St. Louis has triumphed six times in 18 appearances as underdogs of at least +121 on the moneyline, indicating a 45.2% chance of victory in this matchup lbc customer service hotline.

Cubs Recent Betting Performance

Throughout their last 10 games, the Cubs have emerged as the moneyline favorites seven times, winning five of those contests. In those 10 outings, they hit the over on the total runs five times. Against the spread, they hold a 4-6-0 record over their recent games.

Cubs Recent Stats

• Record: 6-4
• Runs Per Game: 4.7
• Home Runs: 12
• ERA: 3.41
• K/9: 5.7

Cubs Player Insights

Kyle Tucker leads the Cubs with a .287 batting average, 17 home runs, and 52 RBIs, ranking 22nd in homers and 25th in RBIs in the majors. Pete Crow-Armstrong is batting .265 with 20 doubles, four triples, 21 home runs, and 16 walks, ranking eighth in home runs and ninth in RBIs across MLB.

Seiya Suzuki tops the team with 23 home runs and 73 RBIs, maintaining a streak of at least one hit in three consecutive games. In his last five outings, he batted 1 phdream.300, including a double, a triple, two home runs, and six RBIs. Meanwhile, Hoerner is at .285 with 17 doubles, one triple, three home runs, and 19 walks.

Cubs Team Props

• Nico Hoerner: Hits O/U 0 bs casino.5 (-245), Total Bases O/U 1.5 (+150)
• Michael Busch: Hits O/U 0.5 (-220), Total Bases O/U 1.5 (+120)
• Ian Happ: Hits O/U 0.5 (-270), Total Bases O/U 1.5 (+100)
• Dansby Swanson: Hits O/U 0.5 (-245), Total Bases O/U 1 337 jili.com.5 (+120)
• Carson Kelly: Hits O/U 0.5 (-220), Total Bases O/U 1.5 (+135)

Cardinals Recent Betting Performance

The Cardinals have faced as underdogs in seven out of their last 10 games, achieving a 3-4 record in those matches. In total run games, they’ve combined with opponents to exceed the total three times in the last 10 games, while holding a record of 6-4-0 against the spread.

Cardinals Recent Stats

• Record: 5-5
• Runs Per Game: 3.7
• Home Runs: 13
• ERA: 4.03
• K/9: 7.3

Cardinals Player Insights

Brendan Donovan currently leads the Cardinals with a .293 batting average while Nolan Arenado has 13 doubles, a triple, 10 home runs, and 24 walks, but is hitting .247. Willson Contreras has been a key player with 11 home runs and 51 RBIs, and Lars Nootbaar also contributes significantly with 11 home runs of his own.

Cardinals Team Props

• Willson Contreras: Hits O/U 0.5 (-250), Total Bases O/U 1.5 (+120)
• Nolan Gorman: Hits O/U 0.5 (-200), Total Bases O/U 1.5 (+125)
• Nolan Arenado: Hits O/U 0.5 (-210), Total Bases O/U 1.5 (+145)
• Lars Nootbaar: Hits O/U 0.5 (-205), Total Bases O/U 1 jilino1 com you can now claim your free 88 php download.5 (+130)
• Masyn Winn: Hits O/U 1.5 (+190), Total Bases O/U 1.5 (+110)

What factors do you think will influence the outcome of the game between the Cubs and Cardinals?